Almost anything that causes narrowing or obstruction of the bronchial tree may be associated with wheezing and similar symptoms. Foreign matter, trauma, pneumonia, and tumors can produce such narrowing. Some forms of heart disease resemble asthma, and cardiac failure is sometimes diagnosed as wheezing. Blood clots that move from the legs to the lungs, and tumors that produce chemical substances, can also provoke wheezing. Poisoning by insecticides or other cholinergic drugs can induce bronchoconstriction. Certain environmental exposures can bring on asthmalike symptoms, while other diseases such as Loffler’s syndrome and polyarteritis nodosa sometimes resemble asthma. In some foreign countries, parasitic infestation of the lungs must also be considered a possibility among people apparently suffering from asthma. Finally, the upper airway obstruction sometimes found after a tracheotomy can cause wheezing that is audible throughout the lungs. The two most common pulmonary problems that are confused with asthma are chronic bronchitis and emphysema. Although the mechanisms involved in these diseases appear to differ, the symptoms are remarkably similar. Chronic bronchitis is an inflammation of the bronchial airways resulting in coughing and excessive mucous secretion. Bronchospasm may also be a major factor, in which case treatment would be similar to that of chronic asthma. Many patients with chronic bronchitis later develop emphysema. A sustained, low level of oxygen in the blood, along with cardiac problems, is more characteristic of a patient with chronic bronchitis than of a patient suffering from asthma. Diagnosis of emphysema, another disease commonly confused with asthma, should be applied to a destructive process in the lungs involving the air sacs and air ducts. Air sacs that are unaffected often compensate, becoming larger and larger and resulting in a decrease in the blood surface exposed to the gas in extended air sacs. The result of this process is a diminished capacity for the exchange of oxygen and carbon dioxide, accompanied by a loss of elasticity in the tissue, so that the patient cannot inflate and empty the lungs spontaneously. The lungs of an emphysema patient seem to remain inflated. Because emphysema rarely exists in isolation, asthma is sometimes mistaken for emphysema. In either case, the reversible symptoms are all that can be treated.